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 Mail: Cure Blau Syndrome Foundation 1138 Old Esquimalt Rd.   Victoria, BC  Canada V9A4X6

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CRISPR and Blau Syndrome

Updated: Dec 3, 2019



CRISPR/Cas9 is technology for editing genomes by acting like a pair of scissors and cutting and altering strands of DNA. Blau syndrome is the result of a genetic mutation in the NOD2 genome. Because we can identify the specific genetic mutation that causes Blau syndrome it is possible that this technology will help to lead to a cure.


There have been recent "successes" using CRISPR/Cas9 lauded in the media such as this one https://www.sciencenews.org/article/crispr-gene-editing-muscular-dystrophy-symptoms-dogs where dogs with muscular dystrophy had their disease reversed.


CRISPR/Cas9 has also been applied specifically to finding a cure for Blau syndrome. This study recently conducted in Japan and published in the Journal of Allergy and Clinical Immunology gives us hope that in the not too distant future we will see Blau syndrome eradicated.


https://www.jacionline.org/article/S0091-6749(17)30685-1/fulltext


Blau syndrome is an excellent candidate for CRISPR/Cas9 research specifically because the gene mutation is so easily identifiable. At curebs.com we intend to keep Blau syndrome in the spotlight of medical research teams who are working with CRISPR/Cas9 technology.